How severe is CVE-2025-12921?

CVE-2025-12921 has a CVSS 3.x base score of 4.3, rated medium severity. It is exploitable over network with low attack complexity, requires low privileges and no user interaction. Impact on confidentiality is low, integrity none, and availability none.

Is CVE-2025-12921 being actively exploited?

It is not currently listed in CISA's KEV catalog. Its EPSS exploit-prediction score is 1% (40th percentile), an estimate of the probability of exploitation in the next 30 days.

What products are affected by CVE-2025-12921?

CVE-2025-12921 primarily affects Openclinica. In total, 2 product configurations (CPEs) are listed as vulnerable; see the affected-products list for the exact versions.

How do I fix CVE-2025-12921?

Review the linked vendor and NVD advisories for patched versions and mitigations, then upgrade or apply the recommended workaround.

Does CVE-2025-12921 have an EU (EUVD) identifier?

Yes. CVE-2025-12921 is tracked in the ENISA EU Vulnerability Database (EUVD) as EUVD-2025-38721.

When was CVE-2025-12921 published?

CVE-2025-12921 was published on 2025-11-10 and last updated on 2026-06-17.

CVE-2025-12921

CVE-2025-12921 is a medium-severity vulnerability in Openclinica with a CVSS 3.x base score of 4.3. It is not currently listed as actively exploited by CISA, and its EPSS exploit-prediction score is low. The underlying weakness is classified as CWE-91.

Key facts

Severity: Medium (CVSS 3.x base score 4.3)
CVSS v2: 4.0
CVSS v4: 2.1
EPSS exploit prediction: 1% (40th percentile)
Actively exploited: Not listed in CISA KEV
EU (EUVD) id: EUVD-2025-38721
Weakness: CWE-91
Affected product: Openclinica
Published: 2025-11-10
Last modified: 2026-06-17

Description

A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13. Affected by this issue is some unknown functionality of the file /ImportCRFData?action=confirm of the component CRF Data Import. Such manipulation of the argument xml_file leads to xml injection. It is possible to launch the attack remotely. The exploit has been disclosed to the public and may be used. The vendor was contacted early about this disclosure but did not respond in any way.

Frequently asked questions

What is CVE-2025-12921?: A vulnerability has been found in OpenClinica Community Edition up to 3.12.2/3.13. Affected by this issue is some unknown functionality of the file /ImportCRFData?action=confirm of the component CRF Data Import. Such manipulation of the argument xml_file leads to xml injection. It is possible to launch the attack remotely. The exploit has been disclosed to the public and may be used. The vendor was contacted early about this disclosure but did not respond in any way.
How severe is CVE-2025-12921?: CVE-2025-12921 has a CVSS 3.x base score of 4.3, rated medium severity. It is exploitable over network with low attack complexity, requires low privileges and no user interaction. Impact on confidentiality is low, integrity none, and availability none.
Is CVE-2025-12921 being actively exploited?: It is not currently listed in CISA's KEV catalog. Its EPSS exploit-prediction score is 1% (40th percentile), an estimate of the probability of exploitation in the next 30 days.
What products are affected by CVE-2025-12921?: CVE-2025-12921 primarily affects Openclinica. In total, 2 product configurations (CPEs) are listed as vulnerable; see the affected-products list for the exact versions.
How do I fix CVE-2025-12921?: Review the linked vendor and NVD advisories for patched versions and mitigations, then upgrade or apply the recommended workaround.
Does CVE-2025-12921 have an EU (EUVD) identifier?: Yes. CVE-2025-12921 is tracked in the ENISA EU Vulnerability Database (EUVD) as EUVD-2025-38721.
When was CVE-2025-12921 published?: CVE-2025-12921 was published on 2025-11-10 and last updated on 2026-06-17.

References

Affected products (2)

cpe:2.3:a:openclinica:openclinica:3.12.2:*:*:*:community:*:*:*
cpe:2.3:a:openclinica:openclinica:3.13:*:*:*:community:*:*:*

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